Hand, foot and mouth vaccine, referred to as ev71 vaccine, is processed and developed from the intestinal ev71 virus that causes hand, foot and mouth in humans. After inoculation in the body, it will stimulate children’s bodies to produce protective antibodies against the hand, foot and mouth virus, which effectively reduces the probability of hand, foot and mouth disease, thus safeguarding the health of children. Hand, foot and mouth disease is an acute infectious disease caused by more than 20 kinds of enterovirus infections, the incidence of the population of children under the age of 5 years, highly contagious, spread through close contact, mainly through the mouth or respiratory tract into the body caused by infection. Usually manifested as fever, herpes, ulcers, cough, loss of appetite and other symptoms, can be treated with medication to relieve symptoms and control the condition, such as ibuprofen, amoxicillin, acetaminophen, etc. Surgery is generally not required. Medications need to be used under the guidance of a medical professional and should not be used arbitrarily on your own. Vaccination with safe and effective HFMD vaccine is the most cost-effective means of prevention and control of the disease. The current HFMD vaccine is the EV71 inactivated vaccine, which can generally be used for the prevention of HFMD caused by EV71 infection in children aged six months to five years old, with basic immunization of two doses at one-month intervals, and is encouraged to be completed before 12 months of age.