The detection of Helicobacter pylori a plus sign suggests that the Helicobacter pylori infection is positive, and if acid reflux and other related symptoms occur is the need for antimicrobial treatment. H. pylori is mainly found in the pylorus of the stomach and is prone to symptoms such as acid reflux, bad breath and heartburn after infection. This bacterium is also a major factor in causing gastric ulcers, gastritis, celiac disease, and even stomach cancer. Therefore, generally if there is a positive H. pylori bacteria with related symptoms, anti-H. pylori treatment is needed. For those who are first detected with H. pylori and are asymptomatic, without strong concern and willingness to treat, they can be temporarily observed and regularly re-checked, and eradication treatment should be carried out in time when symptoms appear. For patients with peptic ulcer, gastric mucosal atrophy, chronic gastritis, etc., treatment is necessary if H. pylori is positive.