A leg pain and swelling, may be related to vascular lesions, lumbar spine lesions, inflammation, excessive fatigue and other factors, you need to choose the treatment program according to the specific cause, such as anticoagulation and thrombolysis, surgical treatment, medication, exercise therapy, massage and hot packs. 1. Vascular lesions: lower extremity venous thrombosis or arterial thrombosis and other diseases, can lead to a leg pain and swelling. It is necessary to clarify whether it is venous thrombosis or arterial thrombosis, and give anticoagulation, thrombolysis and other related treatments. 2. Lumbar spine lesions: If there are structural changes in the lumbar spine, such as lumbar disc herniation, etc., which can easily compress the nerve root and produce the symptoms of pain and swelling in one leg, lumbar traction or laminectomy can be considered. 3. Inflammation: If aseptic inflammation of soft tissue or osteoarthritis occurs in one side of the lower limb, the inflammation stimulation will easily cause soreness and swelling symptoms. Rest should be strengthened and non-steroidal anti-inflammatory drugs, such as meloxicam, should be taken as prescribed by the doctor for treatment. 4. Excessive fatigue: If you carry more weight on one leg for a long time, one leg may become sore and swollen. You need to take more rest. If the symptoms are serious, you can relieve them by exercising, stretching, and massaging with hot compresses. A leg soreness and swelling is recommended to consult a doctor in a timely manner, after the cause of the disease is clear, targeted treatment, to avoid delays in the condition.