The reason you can’t take a cephalosporin the next day after drinking alcohol the first night is because alcohol and cephalosporin antibiotics can produce a disulfiram-like reaction. Since everyone’s body is different and alcohol is metabolized at different rates, studies have shown that drinking alcohol and then taking a cephalosporin within a week of each other can result in a disulfiram-like reaction. Drinking alcohol on the first night, the alcohol may not be fully metabolized, then take cephalosporin may appear disulfiram-like reaction, the patient will be manifested as flushing, palpitations, chest tightness, shortness of breath, nausea, vomiting, blood pressure drop, heart rate increase, serious arrhythmia, cardiac arrest. Therefore, cephalosporin antibiotics can be applied only after one week, and after applying cephalosporin antibiotics, it is also important to pay attention to not drink alcohol for more than one week.