A puppy bite that bleeds is a tertiary exposure and should be treated promptly to avoid rabies virus infection. Whether the puppy is domestic or not, the wound needs to be disinfected in a timely manner, and within 24 hours to the hospital for the first injection of rabies vaccine; if it has been more than 24 hours, should also be early vaccination, and according to the specific circumstances of the appropriate application of drugs for treatment. 1, disinfection treatment: puppy bite skin out of a little blood, need to be disinfected in a timely manner, the first should try to squeeze out the dirty blood, and use a lot of flowing Clear water or soapy water to the affected area rinse 15-30 minutes. If you have the conditions, you can also use iodophor, alcohol and other disinfection, you can also go to the hospital to use hydrogen peroxide and other disinfection solutions for disinfection; 2, vaccination: If you have been vaccinated rabies dog bite, you can choose the “ten-day observation method” to closely observe after the first injection of rabies vaccine, in order to clarify whether you need to inject the remaining injection. If the puppy remains healthy for 10 days without any abnormal symptoms, there is no need to continue the rabies vaccination. If the puppy shows abnormal symptoms or even dies within 10 days, or if the patient has fever, swollen lymph nodes, and obvious swelling, pain, pus and other uncomfortable symptoms at the affected area, the patient should seek medical attention for appropriate treatment and follow medical advice to finish the remaining rabies vaccine. If you are bitten by a stray dog and bleed a little, you need to go to the hospital promptly and get rabies vaccination at intervals of 0, 3, 7, 14 and 28 days after the bite. If the puppy’s hygiene is poor or survival environment is poorer, which can lead to an increased risk of infection at the affected area, professional doctor’s judgment is required as a basis to clarify whether it is also necessary to inject tetanus shots as well as rabies human immunoglobulin; 3. Medication: the puppy’s saliva contains certain bacteria, so the bite site usually has local redness, swelling, pain, and possible infection, patients can apply erythromycin, Metronidazole and other antibiotic drugs to help prevent infection. Patients also need to take care to protect the affected area from water or airborne bacteria and viruses to avoid triggering infection. For those who have pets, it is important to take care to have them vaccinated in a timely manner and to avoid touching or touching stray animals to avoid re-bites. In addition, rabies vaccine antibodies are usually maintained in the body for 6 months, and the overall validity of the vaccine is 1-3 years; therefore, if you are bitten again within 6 months, you do not need rabies vaccination. If you are bitten again within 6-12 months, you will need to get another 2 doses of the booster vaccine. If you are bitten within 1-3 years, you will need a 3-dose booster vaccine.