Obstruction causes high creatinine after lifting the obstruction, whether creatinine can fall and how long it takes to fall is related to the cause of obstruction, duration and so on. Generally speaking, creatinine can drop after the obstruction is lifted, but how long it will take for creatinine to drop is not certain. If the obstruction is caused by kidney stones, creatinine can be reduced quickly if the obstruction is lifted in time. However, due to the different severity of obstruction, there are differences in blood creatinine level, the specific time to come down can not be determined. If there is no timely treatment, chronic kidney injury may occur, and even if the obstruction is lifted, the condition may continue to progress, and creatinine is difficult to return to normal level. If the obstruction is caused by renal malignant tumor and so on, compared with the obstruction caused by renal stone and so on, the treatment effect is poorer, even if the obstruction is lifted, the creatinine may fall slowly or continue to rise. Therefore, if obstruction causes creatinine increase, it is recommended to cooperate with professional doctors for standardized treatment as soon as possible and release obstruction in time.