High rheumatoid factor and normal blood sedimentation may be due to rheumatoid arthritis, systemic lupus erythematosus and other diseases, should be further clarified to cause high rheumatoid factor and normal blood sedimentation of such a situation in order to target to take the appropriate drug therapy, surgical treatment and other therapeutic measures. Rheumatoid factor is a kind of autoantibody with high diagnostic value for rheumatoid arthritis. Besides rheumatoid arthritis, high rheumatoid factor can also be seen in systemic lupus erythematosus, desiccation syndrome, scleroderma and other diseases, and blood sedimentation rate is a kind of routine examination, which is commonly used in clinic for observing the efficacy of treatment and condition. Therefore, patients with high rheumatoid factor and normal blood sedimentation should further improve C-reactive protein, other autoantibodies, ultrasound, X-ray and other auxiliary tests to clarify the specific causes of the disease and target treatment. If patients are diagnosed with rheumatoid arthritis, the treatment should be based on medication such as diclofenac, indomethacin, methotrexate, leflunomide, etc. Surgery should be used if necessary. The treatment of SLE is also based on drug therapy, such as prednisone, cyclophosphamide, tacrolimus and so on. Laboratory test results should be interpreted by a professional physician, and patients are advised to go to the rheumatology and immunology departments of regular hospitals for detailed consultation.