The normal value of estradiol in early pregnancy is below 300ng/ml, and it is not possible to judge when there is fetal heart by the specific value. Generally, around 6-8 weeks of pregnancy, fetal buds begin to appear, and then there may be fetal heart, which can be clarified by ultrasound examination of uterine adnexa, and the pulsation of the fetal heart means that the fetus is developing very well at present. Meanwhile, Down’s syndrome screening should be carried out around 15-20 weeks of pregnancy to rule out congenital malformations of the fetus. Usually pay attention to rest and regular checkups, the occurrence of abdominal pain, irregular vaginal bleeding and other adverse conditions need to consult a doctor in a timely manner, regular monitoring of the head circumference, abdominal circumference, biparietal diameter and other indicators to ensure that the fetus is healthy.