Toothache is one of the common symptoms in dentistry, which refers to tooth pain caused by various reasons. Some patients with toothache can get relief by taking oral painkillers, antibiotics and NSAIDs as prescribed by the doctor: 1. painkillers: painkillers such as ibuprofen extended-release tablets can be used to provide initial relief for emergency toothache symptoms; 2. antibiotics: antibiotics such as metronidazole, ornidazole and tinidazole can be used to relieve Tooth pain caused by systemic inflammation such as periodontitis, and tooth pain caused by inflammation such as nerve inflammation and other local infections; 3. Non-steroidal anti-inflammatory drugs: such as acetaminophen and aspirin, etc., which are mainly used to relieve patients’ pain symptoms and adverse reactions such as nausea and vomiting caused by tooth pain. Some patients with severe toothache, in addition to the use of pain-relieving drug treatment, but also need to actively go to the hospital, according to the different causes of treatment, common as follows: 1, pulpitis: can be through the capping pulp surgery priority to retain the patient’s pulp, if the pulpitis is serious can not be retained, can use root canal treatment, open pulp drainage, pulpotomy and other ways to treat the disease and relieve toothache; 2, periapical inflammation: mainly for root canal treatment. If the effect is not good after treatment and the tooth is seriously damaged, the affected tooth can be extracted; 3, peri-coronitis: the blind pocket can be rinsed with physiological saline, and the blind pocket can be sterilized and anti-inflammatory with iodine glycerin; if an abscess is formed locally in the affected area, the abscess can be cut and the pus can be drained; 4, other: dentin allergy requires desensitization treatment of sensitive parts to relieve the symptoms of toothache caused by over-sensitivity; caries, dental trauma, hidden tooth fracture, Toothache symptoms caused by damage to hard tissue, pulp tissue and periodontal tissue, such as wedge-shaped defect, usually cannot be cured, and need to go to the hospital for relevant surgical repair, filling and other treatments.