Toe warts occur as a direct result of HPV infection of the plantar aspect of the foot, and decreased resistance is intrinsic to the development of toe warts. Trauma, sweating, and friction tend to promote the development of toe warts. Toe warts are benign superfluous lesions caused by human papilloma virus invading the plantar skin, so the direct cause is viral infection. Because the virus is an opportunistic infection and is closely related to the immunity of the host, a decrease in the host’s (patient’s) resistance is intrinsic to the occurrence. There are two aspects of resistance here, one is systemic resistance, such as in children, pregnant women, and elderly people, who are in poor health, or who are not well rested, or who have diabetes or oral glucocorticoids. The second is local resistance, such as local skin has been damaged, such as after trauma, friction much cause small breakouts, and then there are calluses, foot odor and other basic changes. At the same time, HPV virus likes hot and humid environment, like to wear leather shoes and other non-breathable shoes, foot sweat, poor hygiene habits, the surrounding environment is humid, etc., are also triggering factors. The toe wart is a common disease, treatment to local freezing, laser-based, but also available crow bile oil external application and other folk remedies, some people can achieve certain results. In addition to treatment, life pay attention to personal hygiene, wear more breathable shoes, if there is a break or trauma should be timely treatment, can be to a certain extent prevent toe warts.