Cerebral infarction without consciousness may be caused by large cerebral infarction, should cooperate with the doctor as soon as possible to improve the imaging examination, to determine the location and area of cerebral infarction, as soon as possible to carry out thrombolysis, to promote wakefulness, dehydration to lower the cranial pressure, nutritional brain cells and antiepileptic treatment, etc., and consider surgical treatment if necessary. If there is no consciousness in cerebral infarction, it is considered that large cerebral infarction causes cerebral edema or cerebral hernia, which leads to the damage of cerebral cortex, the higher center of brain consciousness, or the damage of upward reticular activating system of brainstem to maintain the state of wakefulness, resulting in the loss of consciousness of the patient, and the progression of cerebral edema or cerebral hernia may also compress the respiratory and heartbeat centers of brain and lead to the life-threatening situation. In this case, the location and size of the infarction should be clarified first, and a reasonable treatment plan should be formulated in time, including the application of thrombolytic therapy, awakening therapy, dehydration and cranial pressure reduction therapy, nutritional brain cell therapy and anti-epileptic therapy. If the cerebral infarction is unconscious and the condition is critical, it is recommended to cooperate with doctors to adjust the treatment plan as soon as possible, and if necessary, adopt decompression surgery of debridement to control and alleviate the condition. After the operation, comprehensive treatment is also needed to promote the recovery of the patient’s consciousness.