Children with single atrium and single ventricle are likely to survive, but will have severe ischemia and hypoxia. Patients with single ventricle are more severely ill than those with single atrium, and their hypoxic manifestations are evident at birth and their survival rate is even lower. As single-ventricle and single-ventricle patients grow older, the ischemic and hypoxic symptoms gradually worsen, seriously affecting the growth and development of the child, and if left untreated, most will not survive into adulthood. Most children die of heart failure, arrhythmia, pulmonary embolism, and respiratory failure within one year of age. Single atrium and single ventricle can be treated surgically, and the success rate of surgery is now higher. After surgery, the patient’s ischemic and hypoxic symptoms are significantly improved, and the patient’s life expectancy is significantly longer. The earlier the age of surgery, the better the surgical outcome and the longer the survival time of the child. However, even if the surgery is successful, the life expectancy and quality of life are still significantly lower than those of normal people.