Urethral pain during urination is usually considered to be related to urinary tract infections, prostatitis, urinary stones, and urinary tract tumors. 1. Urinary tract infection: Urinary tract infection is due to certain pathogenic bacteria, and break through the body’s defense system and the onset. The main symptoms of urinary tract infection are frequent urination, painful urination, urgency of urination, as well as low back pain, chills, high fever, etc. There may be hidden pain in the urethra when urinating. 2. Prostatitis: The main symptoms of prostatitis include abnormal urination, sexual dysfunction, increased nocturia, etc. When the symptoms are mild, there will be pain in the urethra when urinating. 3. Urinary stones: The main symptoms of urinary stones include painful urination, dribbling urination, and even difficulty urinating. Especially the anterior urethra stone, urine flushing will make the stone stimulate the urethra, may appear when urinating urethral pain. 4. Urinary system tumor: The main symptoms of urinary system tumor include pain in urination, hematuria, difficulty in urination and so on. Early pain of urinary system tumor is not obvious, which may cause vague pain in urethra when urinating. Urethral pain during urination may also have other reasons, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then carry out targeted treatment or therapy under the guidance of the doctor.