Amoxicillin and azithromycin have different mechanisms of bacterial inhibition, and different drugs should be chosen according to different bacteria, there is no such thing as which one is better. Amoxicillin is penicillin, a broad-spectrum antimicrobial drug, mainly inhibits the synthesis of bacterial cell wall, mainly used for pneumococcus, anthrax bacillus, tetanus bacillus and so on. Azithromycin is a macrolide, antibacterial spectrum is narrower, mainly inhibit bacterial protein synthesis, mainly used for staphylococcus aureus, streptococcus, etc. Suitable antibiotics should be selected according to drug sensitivity test. When a bacterial infection occurs, you should go to the hospital in time, and choose the most suitable current medication under the comprehensive judgment of a professional doctor to treat the disease.