Coma after brain metastasis of breast cancer can improve the prognosis and prolong the life of patients through radiotherapy, targeted therapy and immunotherapy. Coma after brain metastasis of breast cancer suggests that it has entered the advanced stage of cancer and the prognosis is poor. Through the comprehensive treatment of radiotherapy, targeted therapy and immunotherapy, it can kill part of the tumor cells and shrink the primary and metastatic foci of the tumor, so as to improve the quality of life of the patients and improve the prognosis of the disease. Patients can choose chemotherapy drugs such as paclitaxel, vincristine, cytarabine, etc.; targeted drugs such as bevacizumab, trastuzumab, etc., and immunotherapy drugs such as pembrolizumab. Drugs need to be used in strict compliance with the doctor’s instructions, the emergence of adverse reactions recommend timely medical treatment, drug allergy is prohibited.