As a kind of anti-neovascularization targeted drug for gastric cancer, Apatinib can be replaced by other kinds of anti-neovascularization targeted drugs or chemotherapy to control the disease after drug resistance. 1. Other anti-neoangiogenesis targeted drugs: after taking abatinib, gastric cancer patients can replace other anti-neoangiogenesis targeted drugs such as erlotinib and bevacizumab. They can continue to inhibit tumor progression by blocking the neoangiogenesis of gastric cancer tumor. 2. Chemotherapy: chemotherapeutic drugs such as irinotecan, paclitaxel, oxaliplatin, etoposide and so on have cytotoxicity and can kill tumor cells directly. Gastric cancer patients taking Apatinib can choose chemotherapy to control the progress of disease after resistance. Gastric cancer patients need to go to the hospital in time after taking Apatinib resistance, and make appropriate treatment plan according to their specific conditions under the guidance of doctors.