How long can patients with chronic obstructive pulmonary disease live on a ventilator can not be generalized, the specific survival time is related to the patient’s lung function, complications, underlying diseases, the number of acute exacerbations, treatment methods and effects, physical condition and other factors, in general, good lung function, fewer complications, fewer underlying diseases, fewer acute exacerbations of the patient’s disease has a better prognosis. Chronic obstructive pulmonary disease (COPD) is a devastating lung disease characterized by incompletely reversible airflow limitation, which usually develops in a progressive manner, so patients with COPD are often combined with varying degrees of dyspnea in the later stages of the disease. Ventilator home oxygen therapy is an effective therapeutic measure to improve the symptoms of patients with chronic obstructive pulmonary disease (COPD) and reduce the acute exacerbation of the disease, which can improve the quality of life of patients with COPD. In addition to this, the ventilator is also a powerful respiratory support for the acute exacerbation of patients with COPD, which can reduce the burden on the lungs in the acute stage, and some patients can still live a normal life after getting off the ventilator. It is important to note that patients with COPD can improve their prognosis and reduce the adverse effects of the disease through regular medication and long-term home oxygen therapy, and many patients can work and live as normal after treatment. It is recommended that patients with chronic obstructive pulmonary disease experience discomfort, timely hospital consultation, and actively carry out regular treatment in order to prolong life.