When H. pylori is positive and asymptomatic, the need for treatment is determined by the actual condition. Helicobacter pylori is a common causative agent for infection of gastritis and peptic ulcers. For patients with a family history of gastric cancer, peptic ulcers, and a history of gastritis, the absence of symptoms is also a need for treatment to avoid gastritis and ulcers. For patients with no history of the disease and no symptoms, it can be corrected by improving diet and exercising appropriately first. The treatment of Helicobacter pylori can use quadruple therapy, i.e., omeprazole, bismuth potassium citrate, amoxicillin, clarithromycin four kinds of drugs for the eradication of Helicobacter pylori. Daily attention should be paid to dietary hygiene, washing hands before and after meals, paying attention to oral hygiene, to avoid disease entering by mouth, and also avoid sharing tableware with others to reduce contact, regular checkups to observe the cure of Helicobacter pylori. Please follow the doctor’s prescription for medication.