Diabetics taking alpha-glucosidase inhibitors, such as acarbose, are known to take the first bite, but there are several other issues that need attention when taking such drugs, and I wonder if you have paid attention to them? First, glycosidase inhibitors may cause abdominal distension, increased anal exhaustion, also diarrhea, abdominal pain, therefore, patients with hernia or intestinal obstruction, patients with significant digestive and absorption disorders, and sugar lovers who are taking laxatives or antidiarrheal drugs are not allowed to use. Secondly, severe ketosis, diabetic coma, severe infection or trauma, pregnant and lactating women and children, as well as those who are allergic to α-glucosidase inhibitors are prohibited. The application of α-glucosidase inhibitor alone usually does not cause hypoglycemia, but when combined with other hypoglycemic drugs or insulin, hypoglycemia may occur. It needs to be noted that immediate oral or intravenous glucose treatment should be administered. And treatment with general sugar food (such as steamed bread, fruit juice and other food) is ineffective, because the alpha-glucosidase activity is inhibited, the digestion and absorption of polysaccharide and disaccharide is blocked, and the blood glucose level is unable to rise rapidly. Finally, concomitant administration of α-glucosidase inhibitors with antacids, digestive enzyme inhibitors, choleretic amines, and intestinal adsorbents should be avoided as much as possible, as the latter can weaken the efficacy of the former. Patients who are taking acarbose or voglibose must be aware of these issues!