The peeling and cracking of the soles of the feet may be tinea pedis and hereditary palmoplantar keratosis, which should be treated with topical and oral medications. 1. Tinea pedis: it is caused by fungal infection, topical medication: different treatments should be chosen according to different clinical types, such as dry cracks can be applied first with topical creams, ointments such as vitamin A cream, or salicylic acid ointment, etc., and it is not advisable to use drugs with strong peeling properties. Systemic medication: itraconazole or terbinafine can be taken orally. If tinea pedis is secondary to bacterial infection, antibiotics such as cefaclor should be combined, and anti-allergic drugs such as levocetirizine should be given if tinea pedis is triggered. 2. Hereditary palmoplantar keratosis: local use of retinoic acid cream, urea cream or salicylic acid ointment sealing package, soften the keratin, the appropriate application of glucocorticoid preparations, such as dexamethasone, can improve the therapeutic effect, you can also take the topical application of calcipotriol ointment. In more serious cases, oral administration of avitamin A ester or isotretinoin can also be taken. It is recommended to consult a doctor in time to clarify the cause of the disease and treat the symptoms, so as not to delay the condition.