For patients with advanced ovarian cancer, 6~8 courses of chemotherapy are usually needed, so even if ca125 reaches normal range, it is recommended that patients should standardize chemotherapy according to the course of treatment. Patients with advanced ovarian cancer have metastasis in lymph nodes or distant organs, so the prognosis is poorer. For patients who have lost the chance of surgery or surgery is difficult to completely remove the lesions, standardized chemotherapy can improve patients’ quality of life, reduce recurrence and prolong the survival time, so even if ca125 reaches the normal range, chemotherapy should be completed in accordance with the course of treatment. For patients with advanced ovarian cancer, it is also necessary to pay attention to regular review of tumor markers, CT and other related examinations to assess the change of condition. If abnormal lesions are found, they should be alert to the possibility of disease progression, and it is recommended that they should go to gynecology department of regular hospitals for consultation, and then under the guidance of doctors, they should be treated positively after clarifying the causes.