I. Tumor size The size of the tumor has been repeatedly proven to be one of the most important prognostic indicators of breast cancer. Many studies have shown that the survival of breast cancer patients varies in a stepwise manner depending on the size of the mass: the larger the mass, the shorter the survival period. The size of the tumor is also directly related to axillary lymph node metastasis and distant metastasis. The metastasis of lymph nodes and the number of metastasis are also one of the most important prognostic indicators of breast cancer. The prognosis is better if there is no lymph node metastasis, and worse if there is metastasis. The number and location of lymph node metastases have a greater impact on the prognosis of those with lymph node metastases. The higher the number of metastatic lymph nodes, the worse the prognosis. In addition, the location of lymph node metastasis is also related to the prognosis, the higher the metastasis location, the worse the prognosis. According to the WHO histological classification, breast cancer can be divided into two categories: non-invasive and invasive. The prognosis of non-invasive carcinoma is significantly better than that of invasive carcinoma. Non-invasive carcinomas include: intraductal carcinoma and lobular carcinoma in situ. Among invasive carcinomas, ductal carcinoma is common, accounting for about 65%-80%, while the rest are called special types of carcinoma. Based on the prognosis, special types of cancer can be classified into good, intermediate and poor prognosis. The types of breast cancer with good prognosis are: adenoid carcinoma; invasive sieve-like carcinoma; mucinous carcinoma. The types of breast cancer with intermediate prognosis are: medullary carcinoma; invasive lobular carcinoma. The types of breast cancer with poor prognosis are: carcinoma with chemosis; indolent cell carcinoma; inflammatory breast cancer; lipid-rich carcinoma. Histopathological grading of breast cancer is a valuable prognostic indicator for early breast cancer: grade I and II have good prognosis, grade III has poor prognosis. V. Other histopathological properties Vascular infiltration of tumor is a collective term for lymphatic infiltration and vascular infiltration of tumor. The prognosis is not good with vascular infiltration. Generally speaking, hormone receptor positive tumors are better differentiated, less likely to have visceral metastasis and sensitive to endocrine therapy, while receptor negative breast cancer is poorly differentiated, prone to visceral, especially liver and brain metastasis, and less responsive to endocrine therapy. VII. There is a relationship between the expression of oncogene Her-2/neu and breast cancer prognosis. The overexpression of Her-2/neu protein is currently considered as an indicator of poor prognosis in breast cancer patients with lymph node metastasis. In contrast, the prognostic value of Her-2/neu in the lymph node negative group of patients is controversial.