The side effects of the painkiller Ibuprofen mainly include digestive side effects and neurological side effects, as well as some extremely rare side effects such as lower limb edema, rash, asthma, leukopenia, and so on. 1. Digestive system side effects: Ibuprofen belongs to the non-steroidal anti-inflammatory drugs, with antipyretic and analgesic effects. It itself has a certain gastrointestinal irritation, after taking it may produce stomach pain, heartburn, nausea, vomiting and other adverse reactions. The original digestive system disease patients will be more obvious symptoms, but generally do not have to stop taking the drug, continue to take can be tolerated. 2. Neurological side effects: a small number of patients taking ibuprofen will have neurological side effects, including headache, dizziness, drowsiness, tinnitus, etc., after stopping the drug for a period of time, the adverse reactions can automatically disappear. 3. Others: some extremely rare side effects such as lower limb edema, rash, asthma, leukopenia. The use of the drug needs to be under the guidance of a doctor, unauthorized use of the drug is prohibited.