Serum γ-glutamyl transpeptidase 80U/L is high, it is recommended to clarify the specific cause of the disease. The normal reference range of serum γ-glutamyl transpeptidase is 3 to 50 U/L. It is widely distributed in human tissues, including liver, pancreas, kidney, etc. It is mainly used to diagnose hepatobiliary diseases, and is an indicator for determining biliary obstruction and hepatitis activity; therefore, serum γ-glutamyl transpeptidase 80 U/L is elevated. Causes of elevated γ-glutamyl transpeptidase include viral hepatitis, primary or metastatic hepatocellular carcinoma, obstructive jaundice, myocardial infarction, fatty liver, and biliary tract infections. It is necessary to combine the patient’s symptoms, liver function, liver ultrasound, abdominal CT and other tests to clarify the specific causes. Serum γ-glutamyl transpeptidase may indicate a variety of diseases, and it is recommended to consult a doctor in time and improve further examination to clarify.