The prevalence of hyperuricemia in Chinese adults often reaches about 8.4% to 13.3%, especially middle-aged and elderly men and postmenopausal women are the high prevalence group. In recent years, with the improvement of living standards and changes in dietary habits, the trend of rejuvenation of patients with hyperuricemia and gout has become more and more obvious, and this phenomenon has attracted great attention from the Chinese medical community, and a national standard guideline for the diagnosis and treatment of nephrotic hyperuricemia has been formulated in 2017 to standardize treatment. Nevertheless, many patients with hyperuricemia and gout lack knowledge or know very little about the causes and consequences of their own lesions, and although they think they are taking standardized medication, they lack the effect of stable treatment, and even more so, they burst out of drug toxicity in the course of treatment causing overlapping or aggravation of the disease. So all these are due to the lack of understanding of the basic characteristics of the occurrence and progression of hyperuricemia and gout. So, there are some things you must know about hyperuricemia and gout behind, otherwise you can’t control this kind of disease by taking medicine for the rest of your life. Gout behind the things let me one by one to tell you: 1, blood uric acid level depends on the body of purine metabolism enzyme activity gout and diet does not have a direct causal relationship. Although gout is caused by hyperuricemia, but 80% of the body’s uric acid comes from the body’s internal, that is, the nucleic acid in the nucleus of human cells after a series of metabolic decomposition to generate uric acid. This metabolic process has a lot of enzymes involved, when the number or ability of these enzymes decline, the decomposition of uric acid will be blocked and a large number of accumulation in the body; in addition, the vast majority of uric acid to be discharged through the kidneys, when renal excretory dysfunction occurs, will also cause obstruction of uric acid excretion; thus, the vast majority of high uric acid blood is due to your own ability (purine metabolism enzymes) can not be caused. 2, the common cause of gout is “small horse-drawn cart” gout patients nearly half of the combined hypertension, obesity, diabetes, coronary heart disease, etc., the vast majority of such diseases belong to metabolic diseases, that is, certain substances such as fat, protein, purine, glucose, etc. in the body metabolism obstacles accumulated in the body and caused by the disease. Gout and diabetes and obesity belong to their own ability to poor, unable to deal with the daily metabolism of substances and the occurrence of a group of diseases, with a more graphic words to explain — is “small horse-drawn cart”. 3, gout disease on the health threat is not joint pain gout although frequent cause joint swelling and pain, but it is not enough to cause serious consequences. The risk behind recurrent gout attacks is to induce coronary heart disease and stroke, which often cause sudden death or heart attack. Some people call the combination of high uric acid and coronary heart disease “gouty heart disease”, which is sufficient to illustrate the close synergy between gout and cardiovascular and cerebrovascular diseases. In addition, hyperlipidemia or high triacylglycerol (triglyceride) anemia is obviously related to the increase of blood uric acid, a study found that 75% to 80% of patients with gout are accompanied by hyperlipidemia, while 60% to 80% of patients with hyperlipidemia are accompanied by hyperuricemia. Hyperuricemia and hyperlipidemia can accelerate the hardening or calcification of blood vessels, and they are also the important pushers of triggering damage to the heart, brain, kidneys and other organs. 4, gout and obesity is “brother” gout is mostly seen in obese people. Obesity caused by hyperuricemia may be associated with endocrine system disorders or ketogenesis excessive inhibition of uric acid excretion. Obese people increased energy intake, purine metabolism accelerated can also lead to increased blood uric acid concentration. Gout patients do not lose weight, all the treatment is equal to “white treatment”. 5, the treatment of gout is not only lower uric acid Although gout and hyperuricemia, but lowering uric acid is not the only measure to treat gout. As mentioned earlier, 80% of the uric acid comes from the metabolism of human cells, only 20% from purine-rich foods (such as animal offal, seafood, mushrooms, etc.), so gout patients can not only focus on how to lower uric acid, but also focus on searching for the causes of high uric acid, especially endogenous causes, such as: leukemia, myeloma, erythrocytosis, rhabdomyolysis, strenuous exercise, obesity, tumors, radiotherapy, chemotherapy, etc. can cause high uric acid. radiation and chemotherapy can cause elevated uric acid. In addition, metabolism of uric acid enzyme problems, high uric acid tends to be more serious, renal insufficiency caused by hyperuricemia simply lower uric acid is unable to improve the condition. 6, stop using uric acid drugs than taking uric acid medicine is more important to cause uric acid elevation of commonly used drugs are diuretics, anti-tuberculosis drugs, tumor chemotherapy drugs, immunosuppressants and aspirin, etc., or by increasing cellular decomposition or inhibit uric acid by the kidneys to inhibit the excretion of the pathway leads to its accumulation in the body. For patients with combined hyperuricemia, it is necessary to investigate the above triggers before deciding on the treatment plan. There are many varieties of drugs to lower uric acid, commonly used allopurinol, although cheap, but very easy to cause allergies and blood cell damage, or worse, lead to sudden death, so the clinician has been careful to use this drug. Legend has it that many herbal remedies can cure gout, but the jungle stuff must be seen to be believed.