Multiple lipomas do not require treatment if they are asymptomatic and do not affect your life; if they are painful or aesthetically displeasing, surgery is required. Lipomas are tumors of normal fat-like tissue that appear in fatty areas of the body, such as the back, neck, and buttocks. When multiple lipomas are present throughout the body and are small or asymptomatic, treatment is usually not necessary and regular observation is required. However, if the lipoma is large, or if there is pressure on the peripheral nerves, resulting in numbness and pain, surgical treatment is needed to perform lipoma excision. After the surgery, attention should be paid to wound cleaning, timely change of medication, and generally prevent the use of antibiotics, such as amoxicillin, in order to prevent infection, and the stitches can be removed in 7 days after the surgery. The appearance of multiple lipomas of different sizes on the body, it is recommended to go to a regular hospital specialist in time, and follow the doctor’s instructions for examination and treatment.