Symptoms of advanced malignant brain tumors are usually headaches. These are headaches that cannot be ameliorated by ordinary medications, and often require appropriate control and relief by toxic anesthetics such as dulcolax and morphine, and the attacks are very frequent, even persistent headaches. There will also be persistent epilepsy, especially in the later stages, often with prolonged convulsions that need to be relieved only by intravenous pump administration. Overall generalized weakness, that is, increased protein loss and consumption, body wasting, some people may have sodium and water electrolyte disorders, and others may have symptoms of coma due to tumor compression of the brain, or blockage of the normal circulation of the cerebrospinal fluid pathway caused by hydrocephalus of the corresponding symptoms, such as urinary and fecal incontinence, walking dysfunction, cognitive dysfunction, and even more serious may be coma In the more severe cases, coma may occur, resulting in respiratory and circulatory failure and death.