Diagnosis of bacillus-negative tuberculosis: Bacillus-negative tuberculosis is defined as tuberculosis with three sputum smears and one negative culture, and the diagnostic criteria are: 1. typical clinical symptoms of tuberculosis and chest X-ray. 2. 2. Effective anti-tuberculosis treatment. 3, other non-tuberculous lung diseases can be excluded clinically. 4, Strongly positive PPD (5TU); positive serum anti-tuberculosis antibody. 5, sputum TB bacillus PCR + probe test is positive. 6.Extrapulmonary histopathology confirmed tuberculosis lesion. 7.BALF detects acid-resistant branching bacilli. 8.Bronchial or pulmonary histopathology confirmed tuberculosis lesion. The diagnosis can be confirmed by having 3 of 1~6 or any 1 of 7~8. Definition: Bacteria-negative tuberculosis is defined as tuberculosis with three sputum smears and one negative culture, and the diagnostic criteria are: 1. 2. Effective anti-tuberculosis treatment. 3, other non-tuberculous lung diseases can be excluded clinically. 4, Strongly positive PPD (5TU); positive serum anti-tuberculosis antibody. 5, sputum TB bacillus PCR + probe test is positive. 6.Extrapulmonary histopathology confirmed tuberculosis lesion. 7.BALF detects acid-resistant branching bacilli. 8.Bronchial or pulmonary histopathology confirmed tuberculosis lesion. The diagnosis can be confirmed by having 3 of items 1 to 6 or any 1 of items 7 to 8.