Elevated bilirubin is seen in viral hepatitis, choledocholithiasis, autoimmune hemolytic anemia and other diseases, which are treated with medication or surgery depending on the cause. 1. Viral hepatitis: Viral hepatitis leads to destruction of liver cells, impaired liver function, and impaired bilirubin metabolism, thus leading to elevated bilirubin. It can be treated with antiviral drugs such as entecavir, and liver-protecting drugs such as glycyrrhizic acid preparations and silymarin preparations. 2. Choledochal stone: Choledochal stone will lead to the obstruction of the duct and the reflux of bile acid, which will cause the elevation of bilirubin. Surgery should be carried out in time to remove choledocholithiasis, relieve the obstruction of bile ducts and make bilirubin excretion smooth, so as to reduce bilirubin. 3. Autoimmune hemolytic anemia: autoimmune hemolytic anemia will have a large number of red blood cell destruction, resulting in increased production of bilirubin and elevated bilirubin. Dexamethasone, methylprednisolone and other glucocorticoid drugs should be used in time to control the condition, and splenectomy can be considered if drug treatment is ineffective. The most common manifestation of elevated bilirubin is yellowing of the skin and cornea, etc. If the above symptoms occur or elevated bilirubin is detected, the patient should consult with the attending doctor for further examination and bilirubin-lowering treatment according to the doctor’s instruction after the cause of the disease is clarified.