Cirrhosis of the liver due to the destruction of liver sinusoidal tissue in the liver and other reasons will lead to liver atrophy and become small, this performance is mostly seen in the decompensated stage, need to pay attention to take medication and surgery and other measures to intervene. When cirrhosis enters into the decompensated stage, the liver sinusoids are destroyed by viruses and other reasons, exceeding the recovery ability of the liver, at this time, the liver tissue can not be regenerated and is replaced by the fibrous tissue, and the phenomenon of liver shrinkage and small size occurs. At this time, jaundice, ascites, coagulation dysfunction and other liver function injury manifestations, as well as abdominal wall varicose veins and other portal hypertension manifestations. The treatment of decompensated cirrhosis includes general treatment such as bed rest, prohibition of smoking and drinking, and increasing the intake of vegetables and fruits; medication includes the use of antiviral drugs such as daclatasvir to treat viral infections, liver-protecting treatments such as polyunsaturated phosphatidylcholine, and spironolactone to treat ascaris and other drug treatments. If symptoms such as gastrointestinal bleeding occur in combination, surgical or endoscopic hemostatic intervention is needed; for severe ascites and other conditions, surgical treatment such as portosystemic shunt can be performed as appropriate; liver transplantation is also one of the effective means of treating advanced cirrhosis. Cirrhosis liver atrophy, it is recommended to go to the hospital in time, the above drugs need to be used in accordance with medical advice.