Aspartate aminotransferase 253 u/L does not require special treatment if it is a physiologic cause. If it is caused by fatty liver, cirrhosis and other diseases, it needs to be treated with medication as well as surgery. 1. Physiological causes: Aspartate aminotransferase 253u/L may be caused by prolonged late night, insomnia and excessive exercise. This condition usually does not need special treatment, adjusting the living habits, more rest, and adjusting the dietary habits can be. 2. Fatty liver: Aspartate aminotransferase 253u/L caused by fatty liver needs to be controlled by diet, avoiding high fat and high cholesterol foods, and following the doctor’s instructions to take glycyrrhizic acid preparation, reduced glutathione and other liver-protecting drugs. 3. Cirrhosis: patients can take medicines such as compound turtle shell soft liver tablets and Anluohua Fiber Pill for treatment, and if the symptoms are serious, surgical treatment is needed. Aspartate aminotransferase 253u/L may also be caused by biliary tract disease, liver cancer, alcoholic liver disease, etc., and need to follow the doctor’s advice to use appropriate drugs and surgical treatment.