When high white blood cells cannot be lowered by medication, leukocyte monocloning can be used for treatment, and drugs such as cytarabine and dexamethasone can also be injected intravenously to lower white blood cells. High white blood cells can be seen in bacterial infection, acute myeloid leukemia, acute lymphoblastic leukemia, chronic granulocytic leukemia, chronic lymphocytic leukemia and other diseases. Elevated white blood cells due to bacterial infections do not need to be treated with leukocytes, but can be reduced to normal after anti-infective treatment. Due to leukemia caused by elevated white blood cells, taking medication can not reduce white blood cells, are feasible white blood cell monoculture to reduce the white blood cell count, but can only be temporarily reduced. If the primary disease is not treated, the white blood cell count will rise again. For patients with acute myeloid leukemia, intravenous cytarabine can be used to lower the white blood cell count, and when the white blood cell count is lower than 100*10^9/L, combination chemotherapy can be started to treat the primary disease. For patients with chronic granulocytic leukemia, oral hydroxyurea can be administered to lower the white blood cells at the same time, oral imatinib targeted therapy. For patients with acute lymphoblastic leukemia, intravenous dexamethasone can be used to reduce leukocytes, and combination chemotherapy can be initiated to treat the primary disease after the leukocyte count is below 100*10^9/L. For patients with chronic lymphocytic leukemia, targeted drugs such as ibrutinib can be used, and combination chemotherapy is also feasible. It is recommended that the patient should consult the hematology department in time, and the specialist should formulate an individualized treatment plan according to the patient’s condition.