1, high urine sugar can lead to osmotic diuresis, resulting in a large loss of calcium and phosphorus from the urine, and the negative calcium balance leads to secondary hyperparathyroidism, increased secretion of parathyroid hormone, stimulating osteoclasts and enhancing osteolysis, resulting in bone decalcification and osteoporosis. 2, there are insulin receptors on the surface of osteoblasts, and insulin has a regulatory role in the normal physiological function of osteoblasts. The absolute or relative lack of insulin secreted in the body of diabetic patients makes the osteogenic effect weaken. 3, when diabetes is complicated by renal impairment, the number and activity of renal 1a hydroxylase is reduced, and the synthesis of active vitamin D is reduced, thus affecting the absorption of calcium in the intestine. 4, a considerable number of diabetic patients are complicated by hypogonadism, and the lack of sex hormones will promote and aggravate osteoporosis. 5.When diabetes is combined with microangiopathy and nerve damage, it will affect the nutrient supply of bone, causing osteotropic disorders and bone lesions.