Lymph node hyperplasia for 4 years may be caused by lymphadenitis, lymph node tuberculosis, connective tissue disease and other diseases. General treatment, anti-infection treatment and other measures can be taken. 1. Lymphadenitis: Viral infections such as infectious mononucleosis are one of the most important causes of lymph node enlargement. In addition, localized bacterial infections, such as acute inflammation of the oral cavity and teeth, often cause enlarged lymph nodes in the jaw. In this case, antiviral treatment such as ganciclovir and cefuroxime can be used, and the lymph node swelling can be controlled. 2. Lymph node tuberculosis: it is common to see enlarged lymph nodes in the neck, some of which can be ulcerated and often adhered to the surrounding tissues. Tuberculosis patients need to pay attention to the intake of nutrients and maintain good weight. The treatment requires the joint application of isoniazid, rifampicin and other anti-tuberculosis treatment. 3. Connective tissue diseases: connective tissue diseases such as systemic lupus erythematosus can lead to enlarged lymph nodes. Attention should be paid to bed rest during the flare-up period, and hormone therapy such as prednisone is usually needed. Lymph node hyperplasia for 4 years, it is best to improve the laboratory tests, physical examination, imaging, lymph node puncture, smear and biopsy, in order to find out the cause, if necessary, timely treatment treatment. Drugs should be applied under the guidance of a doctor.