Gui Zhi Plus Long Bone and Oyster Soup can be used to treat persistent premature ejaculation caused by yin and yang imbalance, but it should be used in accordance with the doctor’s prescription. The pathogenesis of premature ejaculation is mainly attributed to the heart, liver and kidney. It is mostly caused by overindulgence in sexual intercourse, over-exertion of the mind and heart, unfulfilled desire, and over-eating of thick flavors and creams. Gui Zhi Plus Long Bone and Oyster Soup is composed of Gui Zhi, Paeoniae Lactiflorae, Ginger, Oyster and other medicines, which has the effect of harmonizing yin and yang, subduing and fixing astringency. It can be used clinically to treat abdominal constriction (body spasms and convulsions due to the feeling of wind-cold), coldness in the pubic region, hair loss, dizziness, palpitations (accelerated heartbeat, often accompanied by panic), enuresis, and loss of spermatozoa in men. Adverse drug reactions or contraindications are not known. Patients who need to use this drug should be under the guidance of a doctor.