Diabetic foot should be actively anti-infective on the basis of strict metabolic control, along with comprehensive and systematic local treatment. 1.Anti-infection treatment Make the blood sugar as close to or as normal as possible, and insulin can be used intravenously. Bacterial infection in superficial parts can be disinfected locally, and fungal infection can be treated with topical antifungal drugs, and tetanus can be prevented at the same time. For deep infections, active debridement and topical application of antibacterial drugs, as well as systemic application of antibiotics according to bacterial culture and drug sensitivity test. 2.Treatment of ulcers After comprehensive assessment of the nature, size and depth of ulcers and exclusion of malignant diseases, thorough and comprehensive debridement, local flushing of ulcers with hydrogen peroxide and potassium permanganate solution daily, local use of insulin, epidermal growth factor and fibroblast growth factor to promote the healing of ulcers. 3.Improve microcirculation Use vasodilator, fibrinolytic and antiplatelet drugs, and if necessary, perform lumbar sympathectomy to improve the blood supply to the foot. 4.Hyperbaric oxygen therapy Hyperbaric oxygen can promote the blood circulation of the whole body, improve the lack of oxygen in the foot and promote the healing of the wound. 5.Nutrition of nerves Vitamin C, vitamin B1, vitamin B12 and vitamin E can be used in large doses to nourish the nerves and promote the repair of damaged nerves. 6.Chinese herbal medicine treatment According to the symptoms, we can treat the symptoms by benefiting Qi and nourishing Yang, nourishing Yin and lowering fire, activating blood circulation, and detoxifying the camp. 7, revascularization and amputation Endovascular stent implantation, angioplasty and vascular bypass surgery can be performed to reduce the rate of amputation due to vascular obstruction leading to gangrene of the extremity, and amputation should be performed if gangrene occurs despite active treatment.