Gastric ulcer and gallstones are different in terms of etiology, clinical manifestations, and treatment methods. 1. Etiology: gastric ulcer can be caused by Helicobacter pylori infection, taking non-steroidal anti-inflammatory drugs, etc.; gallstones are caused by bile stagnation, changes in the physical and chemical properties of bile, and infections. 2. Clinical manifestations: gastric ulcer can have pain in the left upper abdomen, especially after meals, and may also have abdominal distension, loss of appetite and other symptoms; gallstones pain is usually in the right upper abdomen, unrelated to eating. 3. Treatment: gastric ulcers can be treated with gastric acid inhibiting drugs such as omeprazole and lansoprazole, gastric mucosal protective agents such as aluminum thioglycollate, refractory ulcers, hemorrhage and other conditions requiring surgical treatment. Acute attack of gallstones need fasting, gastrointestinal decompression, follow the doctor’s advice to give diclofenac sodium pain treatment, can also use ursodeoxycholic acid choleretic treatment, biliary colic recurrence, accompanied by complications need surgical treatment. Patients with symptoms suspected to be related to gastric ulcers or gallstones are advised to go to the hospital for consultation and active treatment.