Patients experience bitter mouth in the morning, usually caused by bile reflux. Bile can be discharged to the duodenum to participate in the digestion of fat. Under the influence of certain factors, such as gastritis, Helicobacter pylori, cholecystitis, etc., it can cause the dysfunction of the gastrointestinal tract, resulting in the bile entering the duodenum and then not entering the small intestine effectively, which may reverse peristalsis into the stomach, i.e., bile reflux, causing bitterness in the mouth and other manifestations. Therefore, patients can apply drugs that enhance gastrointestinal motility, such as morpholine, to promote peristalsis of gastrointestinal motility. In addition, patients should change the structure of their diet to mainly vegetables and fruits, which is conducive to gastrointestinal peristalsis and better absorption and digestion. Patients with bile reflux are often associated with emotions and exertion, so they should adjust their emotions and maintain a good mood, as well as combine with exercise, such as running, swimming, cycling, etc., to restore gastrointestinal activities to normal and eliminate the symptoms of bitter mouth.