Pertussis, diphtheria, and tetanus vaccine, referred to as pertussis vaccine, is formulated from pertussis vaccine, refined diphtheria, and tetanus toxoid in appropriate proportions for the prevention of three diseases: pertussis, diphtheria, and tetanus. Currently, there are adsorbed pertussis vaccine, diphtheria and tetanus toxoid mixture vaccine (adsorbed diphtheria) and adsorbed acellular pertussis vaccine, diphtheria and tetanus toxoid mixture vaccine (adsorbed acellular diphtheria) in use. The diphtheria vaccine is a national immunization program vaccine, free of charge, and all must be administered. At present, do the more popular quadruple and pentavalent vaccines include diphtheria vaccine? First of all, let’s get to know the quadruple vaccine and pentavalent vaccine. Quadruple vaccine is a multiple vaccine, also known as a combination vaccine, which generally refers to the combination of vaccine components for multiple diseases, so that one vaccination can prevent multiple diseases. A quadruple vaccine is a combination vaccine made from four different antigens combined by a special process. There are many types of combination vaccines, including triple vaccine, quadruple vaccine, pentavalent vaccine and hexadruple vaccine. Among them, the quadruple vaccine is made by combining inactivated and purified antigens of pertussis, diphtheria, tetanus and Hib (Haemophilus influenzae type b vaccine). It can prevent several diseases at the same time: pertussis, diphtheria, tetanus, and diseases caused by Haemophilus influenzae type b such as meningitis, pneumonia, pericarditis, bacteremia, and epiglottitis. According to this definition, multiple vaccines have been used in China for many years: diphtheria and diphtheria vaccine (to prevent diphtheria, pertussis and tetanus) in the last century, and mumps, mumps and leprosy vaccine (to prevent measles, mumps and rubella) and hepatitis A and B vaccine (to prevent hepatitis A and B) in this century. Quintuple vaccine It is actually a quadruple vaccine (polio + poliomyelitis) with Haemophilus influenzae vaccine. The former is a liquid and the latter is a lyophilized powder, and the former dissolves the latter to become the pentavalent vaccine. The two vaccines are produced separately and packaged together to make a pentavalent vaccine. Does the quadruple and pentavalent vaccine include the diphtheria? Is it effective? The combined vaccine can prevent pertussis, diphtheria, tetanus and diseases caused by Haemophilus influenzae type b at the same time. It can replace one type of diphtheria and reduce the risk of pain and adverse reactions in babies by reducing the needles, but it is more expensive than receiving diphtheria and Hib (Haemophilus influenzae type b vaccine) separately.