Itchy eyes in the middle of the night may be related to improper eye use, environmental factors, certain diseases and so on. 1. Eye way: excessive use of eyes, such as gazing at the cell phone, computer and other electronic screens for a long time, can appear dry and itchy eyes and other symptoms. Rubbing your eyes with dirty hands can also cause itchy eyes. 2. Environmental factors: in the air conditioning room, heating room and other air dry environment, can also cause itchy eyes. 3. Disease factors: such as dry eye patients, there will be eye discomfort symptoms, often manifested as dry eyes, itchy eyes, astringent eyes. Blepharitis can appear eye redness, itchy eyes, burning sensation of the eyelid margin. Itchy eyes in the middle of the night, long time no relief, it is recommended to go to the hospital to rule out disease factors.