There is no most effective way to remove dark circles clinically. Dark circles may be caused by physiological factors such as lack of sleep, or by diseases such as post-inflammatory hyperpigmentation, which can be removed through general treatment and medication. 1. Physiological factors: lack of sleep may lead to deepening of the skin around the eyes and the phenomenon of dark circles. You need to adjust your work schedule, develop good sleeping habits, get enough sleep and avoid staying up late. 2. Post-inflammatory hyperpigmentation: The presence of post-inflammatory hyperpigmentation under the eyes can also lead to the formation of dark circles. You need to use niacinamide, azelaic acid cream and other drugs under the guidance of a doctor to reduce hyperpigmentation, and you can also use hydroquinone cream and other drugs to inhibit the formation of melanin, to achieve the purpose of removing dark circles. Sun protection is needed during treatment. People with dark circles are recommended to be admitted to the hospital for examination and standardized treatment after physiological factors are ruled out.