The body long blisters a touch to break are water to consider is pemphigus, herpes zoster or herpes simplex caused by different reasons, different treatment methods. 1. Pemphigus: autoimmune blistering disease caused by epidermal cell laxity, a common autoimmune disease, characterized by blisters on the skin and mucous membranes, with thin blister walls that are easy to break. Treatment, glucocorticoids are the first line of treatment, the early stages of the disease need to be given adequate treatment, combined with immunosuppressants such as cyclophosphamide, etc. to help control the condition and the gradual reduction of hormones. 2. Herpes zoster: an acute infectious skin disease caused by varicella zoster virus infection, some patients may become carriers of the virus after being infected without symptoms. Herpes zoster usually has a zonal distribution of the rash, usually occurring on one side of the body, manifested as clusters of blisters along the peripheral nerves in a group distribution, usually accompanied by pain. Acyclovir tablets, valacyclovir hydrochloride capsules, bromovudine tablets and other drugs can be used as prescribed by the doctor, together with methylcobalamin capsules to nourish the nerves, and pregabalin, gabapentin and so on can be given for obvious pain. 3. Herpes simplex: generally caused by herpes simplex virus infection, mainly manifested as burning skin, cluster blisters, can follow the doctor’s instructions to apply acyclovir tablets, vasiclovir hydrochloride capsules and other treatments. Usually must keep the skin clean, keep ventilating and disinfecting the room every day, and prohibit bathing and scrubbing before the scabs fall off.