Toe seam grew a hard lump like callus a touch of pain may be caused by callus, may also be caused by corns, and may be caused by metatarsal warts, different causes, different treatment methods. 1. callus: callus is commonly known as callus, is a kind of long-term contact friction, resulting in the palm of the foot or palm of the hand local keratinization hyperkeratosis, thickening of the disease. Treatment should try to avoid friction, but also can use keratin stripping agent, such as sulfur salicylic acid ointment for treatment. 2. corns: is a kind of foot skin long-term extrusion, friction and keratin hyperplasia changes, the disease can also lead to patients appear to toe seam grew a hard lump like callus a touch on the pain of the symptoms, the treatment can be used to corns ointment, salicylic acid ointment, urea ointment treatment, but also through the freezing, laser and other methods of treatment. 3. metatarsal warts: metatarsal warts are caused by human papilloma virus infection, occurring on the soles of the feet, common warts, preferably in the front of the metatarsal, but also in the toe joints, the treatment should be to avoid friction, to maintain foot hygiene, treatment can be used to fluoride uracil ointment, imiquimod ointment, salicylic acid ointment, etc., or through the laser, freezing, and other physical ways to remove. In addition to the above diseases, other diseases can also cause patients to appear in the toe seam grows a hard lump like callus when touched the symptoms of pain, it is recommended to consult a doctor in a timely manner, follow the doctor’s instructions to use medication or other treatments.