Gallstones are still painful after hanging water can be treated by changing the medication program or surgery. 1. Drug therapy: if the patient’s pain is serious, can change the drug program, under the guidance of the physician application of scopolamine (oral, intramuscular, static can be), can release the biliary smooth muscle spasm to relieve the pain; can be combined with oral ketotifen, ursodeoxycholic acid and other drugs to treat, and at the same time, can continue to oral or intravenous drip antimicrobial drugs to treat. 2. Surgery: the patient’s condition is more serious, suitable for surgical indications, can be selected under the guidance of the physician surgery (minimally invasive laparoscopic cholecystectomy, endoscopic retrograde pancreatic cholangiopancreatic lithotripsy and endoscopic sphincterotomy lithotripsy, laparoscopic choledochotomy combined with cholecystectomy, etc.) method of treatment. In addition, patients should avoid high fat, high cholesterol diet, such as fat meat, barbecue and other foods, try to light and easy to digest food, you can eat some fresh fruits and vegetables; at the same time, avoid overeating, three meals a day at regular intervals, and must give up alcohol. Gallstones patients need to go to the hospital, by the doctor according to the patient’s condition for treatment.