The difference between hemorrhoid suppositories and hemorrhoid creams is mainly the difference in usage. Hemorrhoid suppositories are rectal medications that are inserted into the anus so that they can be used as a treatment, especially for internal hemorrhoids, and are more effective for the clinical symptoms caused by internal hemorrhoids. Hemorrhoid creams are topical medications that are applied directly to the hemorrhoid area, which can relieve the edema and pain of the hemorrhoid. Both hemorrhoid cream and hemorrhoid suppositories are commonly used to treat hemorrhoids. Clean the perianal area with water before using the medication, which can avoid infection and enhance the treatment effect. Hemorrhoid suppositories and hemorrhoid creams must be chosen according to the specific condition.