Joint pain after taking exemestane is generally an adverse reaction to the drug; it is necessary to analyze whether to change the drug according to the actual situation, if the patient can tolerate the pain is generally not changed, if the pain is serious will consider changing the drug. Exemestane is an antitumor drug for postmenopausal patients with advanced breast cancer whose disease has progressed after tamoxifen treatment. Arthralgia accounted for 18% of the common adverse reactions in patients with early-stage breast cancer treated with the drug, along with mild to moderate hot flashes (22%), fatigue (16%), headache (13.1%), insomnia (12.4%), and increased sweating (11.8%). When the adverse reaction of joint pain occurs, the degree of pain is usually used to determine whether the drug can be continued. If the pain is mild and the patient can tolerate it, the patient can be treated with symptomatic analgesic therapy and continue to take the drug; if the pain is so severe that the patient can not tolerate it, the patient should consult with the doctor and switch to another drug for treatment. If the pain is severe, the patient should consult a doctor to determine the cause of the joint pain and give targeted treatment.