Chemotherapy toe finger ulcers are usually caused by hand-foot syndrome, which can be relieved by applying moisturizing cream, medication, and avoiding squeezing the hand and foot area. Chemotherapy toe and finger ulcers may be caused by hand-foot syndrome, which refers to the application of specific chemotherapeutic drugs, resulting in skin necrosis of adverse reactions, that is, chemotherapeutic drugs kill cancer cells at the same time, but also affect the normal cells, including skin cells, subcutaneous blood vessels, the common adverse reactions to the skin’s tingling, erythema, skin, blisters, and even ulceration, so that the toes and finger areas will be ulcerated. General treatment includes local application of moisturizing cream on the affected area to moisturize the skin. If blistering or peeling occurs, do not tear it with your hands, and you should promptly use sterilized sterile scissors to trim the buckled lesions cleanly, and go to the hospital for treatment if necessary. You can also soak the lesions in warm water to improve the cracking phenomenon. Medication can be used under the guidance of the doctor topical urea cream, vitamin E ointment and so on, if there is a bacterial or fungal infection, you also need to use metronidazole, gramicidin and so on to symptomatic treatment. Usually, you also need to protect your toes and fingers, avoid local extrusion and injury, avoid strenuous exercise, and avoid contact with hot water and detergents. You also need to pay attention to light diet, regular work and rest. Please strictly follow the doctor’s instructions, do not self-medication.