Denosumab is mainly used for giant cell tumor of bone which may lead to serious dysfunction. There are also side effects in the process of use, specifically in the following areas: 1. Some patients may have hypersensitivity reactions. If patients have these allergic reactions, they should immediately stop the drug, symptomatic treatment, and can not use this denosumab again in the future. 2, denosumab may also cause hypocalcemia, so patients should pay attention to check the blood calcium during use. If there is hypocalcemia, hypocalcemia should be corrected first, and during the treatment with denosumab, the blood calcium level should be closely monitored to prevent the occurrence of hypocalcemia. 3. denosumab may cause necrosis of the jaw bone and external auditory canal bone, so special attention should be paid when using it. 4. other side effects have been observed in this clinical application, such as arthralgia, headache, nausea, back pain, and other side effects, headache, nausea, back pain, fatigue, and pain in the extremities. In conclusion, side effects may occur during the use of denosumab and should be closely monitored. Once suspicious symptoms appear, the doctor or pharmacist should be consulted at any time to prevent the occurrence of serious adverse reactions.