Scientists’ observations have shown that both acute and chronic smoking can increase the secretion of gastric acid. The acidity of the duodenum begins to increase 30 minutes after the start of smoking and does not return to normal levels until 30-60 minutes after stopping smoking. 1, Smoking can relax the pyloric sphincter of the stomach, leading to the occurrence of bile reflux. 2, smoking delays the emptying of the stomach and affects the secretion of bicarbonate from the pancreas and duodenum, thus weakening the neutralizing effect of gastric acid. 3, the nicotine in cigarettes directly damage the blood vessels of the mucosa, reducing blood flow to the gastric mucosa. 4, smoking can also reduce the secretion of protective cytokines in the gastric mucosa, these make the gastric mucosa barrier protection is weakened, and lead to peptic ulcer. 5, the study found that the rate of H. pylori infection in smokers is higher than that of non-smokers, and that 73% of the population of smokers infected with H. pylori suffered from ulcer disease, while only 29% of the population of non-smokers infected with H. pylori suffered from ulcer disease. 6, smokers taking NSAIDs are more likely to suffer from ulcer disease and complications than non-smokers taking the drugs. 7, smoking and alcohol, nervousness, fatigue and other factors at the same time, will significantly prolong the ulcer healing time. Smoking at this time is simply adding fuel to the fire! Therefore, for the sake of your health, please quit smoking as soon as possible.