Some people’s toothache is not caused by dental disease, but often caused by other etiologies. 1.Coronary heart disease: Some coronary heart patients have heart pain when the heart symptoms are not obvious, but they have pain on one side or more teeth up and down at the same time. If this “toothache” is treated as a dental disease, it will be misdiagnosed. Nitroglycerin will quickly relieve the symptoms. 2, hypertension: when the blood pressure rises, causing the peripheral small arteries to sclerosis and spasm, it can cause the tooth pulp to bleed and the tooth tissue to be undernourished, resulting in toothache. 3, upper collar sinusitis: the upper collar sinus is one of the paranasal sinuses and is located close to the upper teeth. When the inflammation occurs, it can also affect the teeth and cause toothache. 4.Sanwa neuralgia: Sanwa nerve is a facial sensory nerve, when pain occurs on one side of Sanwa branch, it is similar to toothache. The pain is severe and unbearable, with throbbing pain or stabbing pain. 5.Influenza: caused by influenza virus, often invades the respiratory system. If it invades the oral mucosa and periodontal membrane, there will be paroxysmal swelling and pain in the teeth. Toothache may not always be caused by dental disease, clinical practice has confirmed that some people’s toothache is not caused by dental disease, but often caused by other etiologies. Therefore, it is easy to misdiagnose toothache that occurs in coronary heart disease, and an electrocardiogram should be done first to rule out heart disease when toothache occurs.